Petrodex Daily Dental Bones are treated with a patented dual enzyme that activates the body’s natural defense system killing plaque forming bacteria. Ingredients: Beefhide, Potassium Sorbate (a preservative), Dextrose, Poultry Digest, Natural Flavoring, Primary Dried Yeast, Aspergillus Niger Fermentation Extract, Dried Whey Protein Concentrate. Made in Mexico.